Expired Naloxone is Good Up To 30 Years - Redirect Expired Kits

What You Need To Know

• Expired naloxone should never be disposed of- and if possible, it should be redistributed to communities at the highest risk of opioid overdose*

• Studies have demonstrated that naloxone retains its effectiveness for as long as nearly 30 years past its expiration date. 

• Many grassroots organizations use expired naloxone and have regular reports of successful overdose reversals. 

• A study investigating the impact temperature on Naloxone found that “Naloxone exhibits no changes in drug concentration following exposure to heat or freeze-thaw cycles for up to 28 days compared to Naloxone stored at room temperature.”

• Next Distro accepts donations of expired and expiring naloxone in order to redistribute it. 

Where to Go for More Information

• Can I Use Expired Naloxone - Next

• Opioid overdose reversal products chemically stable past expiration date, study indicates: extended shelf-life has potential for stockpiles and communities, Science Daily

• Naloxone products stay effective long after expiration date, Clinical Advisor

• Legality of Dispensing and Administering Expired Naloxone in Illinois, Network for Public Health Law

• Legality of Dispensing and Administering Expired Naloxone in Georgia, Network for Public Health Law

Programs To Know

• Next Distro : If you have a significant amount of expired or soon-to-expired Narcan nasal spray or intramuscular naloxone that has been properly stored, please reach out to us.

Research

• Quality Assessment of Expired Naloxone Products From First-responders Supplies, Journal Of Prehospital Emergency Care : “Most tested samples were found containing more than 90% of labeled Naloxone, including those stored for nearly 30 years. The Naloxone degradation was slow, but generally correlated with storage time length. There was no significant amount of degradation products detected across all samples.” 

• Evaluation of Chemical Stability of Naloxone Products Beyond Their Labeled Expiration Dates, 2018 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 Annual Meeting. 

• Naloxone Could be Used Past Expiration Date Studies Say, American Pharmacists Association: “The chemical analysis found that 11 of the 12 Naloxone samples retained between 90% - 110% of their potency, the range designated by the USP as meeting the standard for safe and effective use”

• FDA announces shelf-life extension for naloxone nasal spray

• The effects of heat and freeze-thaw cycling on naloxone stability