Polysubstance Use Is Now A Major Driver Of Overdose

What You Need To Know

• The current overdose crisis has moved beyond opioids alone. In 2019, nearly half of drug overdose deaths involved multiple drugs. - CDC Programs must reflect this new reality. 

Where to Go for More Information

• Policy Proposals to Reduce Drug-Related Harm: How To Address the 4th Wave of the Overdose Crisis - Drug Policy Alliance

• Harm Reduction for Stimulant Use - Harm Reduction International, 2019

  
  

• Polysubstance Use Facts

• Stimulant Use: Harm Reduction, Treatment, and Future Directions - Drug Policy Alliance

  
  

• Stimulant Overamping Basics - National Harm Reduction Coalition

• What Is Overamping? - National Harm Reduction Coalition

• Factsheet - Cocaine - Drug Policy Alliance

  
  

• Factsheet - Meth - Drug Policy Alliance

• Safer Drug Use 101 - National Harm Reduction Coalition

• Bevel Up Safer Use Resource Collection - BevelUp and NASTAD             

  
  
  
  

Research

• Patterns and motivations of polysubstance use: a rapid review of the qualitative evidence

  
  

• Reduced drug use as an alternative valid outcome in individuals with stimulant use disorders: Findings from 13 multisite randomized clinical trials - Amin-Esmaeili et al, 2023 

• Motivation and context of concurrent stimulant and opioid use among persons who use drugs in the rural United States: a multi-site qualitative inquiry - Fredericksen et al, 2024

• Incorporating prescription psychostimulants into the continuum of care for people with stimulant use disorder in Canada - Palis and MacDonald, 2023

• Impact of Treatment with Central Nervous System Stimulant and Risk of Substance Use Disorder in Adults with Attention‑Deficit/Hyperactivity Disorder - Jeun and Al‑Mamun, 2024